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Process Biotechnology Fundamentals, 4/e

Process Biotechnology Fundamentals, 4/e

Process Biotechnology Fundamentals, 4/e

  • By: Satya Narayan Mukhopadhyay

₹1,525.50 ₹1,695.00 Save: ₹169.50 (10%)

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ISBN: 9789387692480

Bind: Paperback

Year: 2020

Pages: 668

Size: 6.75 x 9.5 Inch

Publisher: Viva Books Originals

Sales Territory: Worldwide


Newer intellectual challenges for process biotechnology (PB) have emerged with impressive recent progress of gene-concerned and nano-systemic biosystems and the parallel developments in the related instruments/equipment/machines for analytical methodologies. These progresses have convinced universities/institutes and affiliated colleges that biotechnology (BT)/PB is one of the key areas for R&D and education in biochemical engineering/chemical engineering and their related interdisciplinary higher education areas for human resource development (HRD).

This book has the following unique features:

  • Integration of academic and practical bioprocessing principles towards process biotechnology development.
  • Research generated data never before published in a single collated text.
  • Detailed aspects of oxygen mass transfer in biological systems.
  • Ways to control undesirable microorganisms.
  • Provides scope for progressive development in scale up of industrial bioprocessing system.
  • Systematic design engineering calculations of bioprocessing systems.
  • PCR instrumental analysis: theory, engineering and technology.
  • Heat and mass transfer concerns in rDNA bioreactors.
  • Innovative microbial microfermentation equipment and aspect.
  • Nanosystemic PB concerns in bioelectricity generation in biofuel cell.
  • Nanosight instrument and use in analytical biosystems.
  • Enhancing scopes of BTBE in PB and education.
  • Abundance of illustrative tables, figures and mathematical relations.
  • Numerous mathematical problems and multiple choice questions.


Target Audience:

Students of biotechnology and biochemical engineering/chemical engineering.



Preface to the Fourth Edition

Preface to the Third Edition

Preface to the Second Edition

Preface to the First Edition

Chapter 1. INTRODUCTION • Progress of Process Biotechnology • Knowledge Collation and Expansion • Bridging the Gap: Biosciences Engineering and Technology • Global Impacts and Scenario • Forecasting • Further Reading

Chapter 2. ENGINEERING BIOLOGY OF CELLS AND MOLECULES THEY SYNTHESIZE • Cell Biology Events • Structural Engineering of DNA in Advancing Bioprocess Engineering • Biomolecular Design Engineering Tools: Properties and Forefront Applications • Further Reading

Chapter 3. MEDIUM ENGINEERING FOR CELL CULTIVATION AND BIOREACTIONS • Introduction • Basic Concept in Medium Design Procedure • Design Procedure • Basics of Material Balance • Growth Limiting Nutrient in the Designed Medium • Engineered Medium in Cell Growth and Product Formation • Metabolic Engineering • Bioorganic Reaction Medium Engineering • Novel Media • Further Reading

Chapter 4. CONTAMINATION FREE FLUIDS FOR PROCESS BIOTECHNOLOGY • Introduction • Contamination Free Air Supply • Few Non-conventional Airborne Particle Removal Methods • Contamination Free Medium by Sterilization • Further Reading

Chapter 5. CONCERNS OF AERATION AND MIXING/AGITATION IN BIOPROCESSING • Introduction • Oxygen Pathways in Cell Cultivations • Volumetric Oxygen Transfer Coefficient (KLa) • Oxygen Transfer Mechanism and Parameters • Resistances to Gas-Liquid Interface and Bulk Mixing • Recent Concept in Oxygen Transfer Pathway • Mixing/Agitation in Biofluids • Development in Physical Concepts in Liquid Phase Oxygen Transfer Coefficient (KL) • Advances in Oxygen Absorption Mechanism and Influential Factors • Absorption Models • Measurements of Dissolved Oxygen (DO), KLa, and Active Oxygen Species • Gaseous Oxygen Measurement • Assessment of KLa • Estimation of Reactive Oxygen Species • Conventional and Novel Bioreactors for Cell Cultures • Microbial Cell Culture Bioreactors • Mammalian Cell Culture Bioreactors • Importance of KLa in Cell Culture Process Scale up • Acknowledgement • Further Reading

Chapter 6. NEW BIOPROCESSING: ASPECTS AND STRATEGIES • Archaebacterial Bioprocessing: Problems and Developments • Bioprocessing by Cell Synchronization • Recent Advances of Yeast Bioprocessing • Multiinteracting Microbial Bioprocessing: Theory, Benefits and Problems • Strategies of Cycling and Profiling of Variables in Bioprocessing • Further Reading

Chapter 7. BIOREACTORS AND BIOSENSORS • Introduction • Bioreactors in Bioprocessing of Biocell • Enzyme Bioreactors • Biosensors in Bioprocessing • Further Reading

Chapter 8. BIOPROCESSING SCALE UP: CONCERNS AND CRITERIA • Introduction • Scale up Concerns of Microbial, Mammalian and Plant Cell Processes • Scale up Criteria • Selection of Scale up Criteria • Scale up Genetically Engineered Cell Culture Fermentation • Further Reading

Chapter 9. BIOPRODUCTS: MODERN ESTIMATION AND BIOASSAY • Introduction • Online MS Instrumental Analysis • Light Scattering Instrumental Analysis • Chromatography Instrumental Analysis • Flow Injection Instrumental Analysis (FIIA) • PCR Instrumental Analysis • Heat and Mass Transfer in rDNA Fermenter/Bioreactor • Few Bioassay Procedures • Further Reading

Chapter 10. BIOPRODUCTS RECOVERY: CONVENTIONAL AND NEWER METHODS • Introduction • Conventional Recovery Methods • Newer Methods • Further Reading

Chapter 11. TREATMENT BIOTECHNOLOGY OF LIQUID WASTES AND WATER • Introduction • General Concerns and Principles • Treatment Biotechnology for Waste Waters • Potable Water Treatment Biotechnology • Treatment Biotechnology of Genetically Engineered Cell Processing Effluents • Further Reading

Chapter 12. CONTROL OF UNDESIRABLE MICROORGANISMS IN BIOSYSTEMS • Introduction • Methods of Controlling Undesirable Microorganisms • Disinfectant Decay and Bacterial Inactivation Kinetics • Further Reading

Chapter 13. CELLULOSE PROCESSING RELEVANCE TO PROCESS BIOTECHNOLOGY • Introduction • Cellulases: The Complex Resource Conversion Agent • RQ and CQ in T. reesei • Approaches of Cellulosic Bioprocessing and Co-product Utility • Further Scope with Lignocellulose Processing Research • Cocktail Enzyme Use in Polysaccharide Systems • Further Reading

Chapter 14. BIOPROCESSING: USING CELLS UNDER STRESSES • Introduction • Stress Protein Sources and Family Types • Nomenclature of Stress Proteins • Physiological Stress Inducers and Cross Interactive Stresses • SPs Functional Features • Molecular Biology of Cell Processing Under Stress • Kinetics and Dynamics of Stress Proteins Formation • Molecular and Cell Biology (MCB) Techniques in Stress Proteins Analysis • Upstream Bioprocessing and Downstream Separation of SPs • Future Prospects of SPs • Conclusions • Acknowledgement • Further Reading

Chapter 15. BIOPROCESS PLANT DESIGN CALCULATIONS: PENICILLIN PRODUCTION SYSTEM • Introduction • Defining the Design Problem • Fermenter Design Calculation Items • Downstream Process for Recovery by Filtration • Downstream Processing for Extraction • Further Reading

Chapter 16. BIOPROCESSING PRACTICE TUTORIALS • Introduction • Microbial Pure Culture Bioprocessing • Mixed Microbial Cell Cultures • Mammalian Cell Culture System • Plant Cell Culture • Bioproduct Recovery • Additional Practice Tutorials • Miscellaneous Multichoice Questions • Further Reading

Chapter 17. SUBSTRATES FOR INDUSTRIAL PROCESS BIOTECHNOLOGY AND THEIR REFINING • Introduction • Substrates/Resources • Further Reading

Chapter 18. NANOSYSTEMIC PROCESS BIOTECHNOLOGY (PB) • Introduction • In Vitro Nanoprocess Biotechnology • Nanosystemic Biomaterial Resources and Analytical Uses • Zeta Potential Analysis using Z-NTA for Bioparticles of Nano Dimensions • Further Reading




About the Author:

Satya Narayan Mukhopadhyay completed his B.Sc. Honours in Chemistry from Calcutta University, B.Tech and M.Tech in Food Technology and Biochemical Engineering from Jadavpur University, and Ph.D. from the lndian lnstitute of Technology, Delhi. He started his teaching career at Harcourt Butler Technological lnstitute (HBTI), Kanpur and later at IIT Delhi. A recipient of the JSPS Award and Fulbright Fellowship, he is a Life Fellow at the lndian National Academy of Engineering and the lndian lnstitute of Chemical Engineering, and is a Life Member of the lndian Society for Technical Education. He retired as Professor from IIT Delhi and later as an Adjunct Professor, Department of Biological Sciences, Birla lnstitute of Technology and Science, Pilani. Prof. Mukhopadhyay's publications include Oxygen Responses, Reactivities and Measurements in Biosystems, Process Biotechnology Fundamentals (3 Edns.), Advanced Process Biotechnology, Experimental Process Biotechnology Protocols, Process Biotechnology: Theory and Practice and Food Engineering: Process and Technology. He served as an expert member in many selection committees of DBT/CSIR and different universities/llTs/NITs and Gol and delivered invited talks.


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